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New automated testing for the data linking functions by @RohanBhattaraiNP New function to correct subject ids by @AbakahAlexander 

CLI Documentation for Users an expanded CLI file options CLI Documentation for Users by @Kshemaahna in https://github.com/caltechlibrary/caltechdata_api/pull/66 Expanded CLI file options by @Kshemaahna and @tmorrell New Contributors @Kshemaahna made their first contribution in https://github.com/caltechlibrary/caltechdata_api/pull/66 Full Changelog: https://github.com/caltechlibrary/caltechdata_api/compare/v1.10.0...v1.10.1 

Olfactory dysfunction is a common outcome of brain injuries, negatively affecting quality of life. The adult mammalian nervous system has limited capacity for olfactory recovery, making it challenging to study olfactory regeneration and recovery. In contrast, zebrafish are ideal for such studies due to its extensive and lifelong regenerative abilities. In this work, we describe a model of excitotoxic injury in the olfactory bulb (OB) using quinolinic acid lesions in adult zebrafish of both sexes. We observed extensive neurodegeneration in both the OB and olfactory epithelium, including a reduction of bulbar volume, neuronal death, and impaired olfactory function. Recovery mechanisms involved tissue remodeling, cell proliferation, and neurogenesis, leading to full restoration of olfactory function by 21 d. This study provides a model to further investigate the effects of excitotoxicity on olfactory dysfunction and highlights zebrafish's remarkable regenerative abilities, providing insights into potential therapeutic strategies for restoring olfactory function following brain injuries. 

Summary Herbaceous plant species have been the focus of extensive, long‐term research into climate change responses, but there has been little effort to synthesize results and predicted outlooks. This primer summarizes research on climate change responses for eight intensively studied herbaceous plant species. We establish generalities across species, examine limitations, and propose a path forward. Climate change has reduced fitness, caused maladaptation, and/or led to population declines in at least part of the range of all six forb species. Plasticity alone is likely not sufficient to allow adjustment to shifting climates. Most model species also have spatially restricted dispersal that may limit genetic and evolutionary rescue. These results are surprising, given that these species are generally widespread, span large elevation ranges, and have substantial genetic and phenotypic variation. The focal species have diverse life histories, reproductive strategies, and habitats, and most are native to North America. Thus, species that are rare, habitat specialists, or endemic to other parts of the world are poorly represented in this review. We encourage researchers to design demographic and field experiments that evaluate plant traits and fitness in contemporary and potential future conditions across the full life cycle, and that consider biotic interactions in climate change responses. 

We describe a modular design approach for creating versatile DNA origami subunits that can target diverse self-assembled structures. The subunit consists of a constant “core module” with variable “bond modules” and “angle modules” added to its exterior, controlling interaction specificity, strength, and structural geometry. The design features flexible joints between subunits, implemented by using single-stranded angle modules, whose mechanical properties and possible conformations are characterized by cryogenic electron microscopy and coarse-grained molecular modeling. We demonstrate the design’s versatility through the assembly of structures with different Gaussian curvature, including sheets, spherical shells, and tubes. Our findings suggest that incorporating a judicious amount of flexibility in the bonds provides error tolerance in design and fabrication while maintaining target fidelity. Furthermore, off-target assemblies potentially introduced by flexibility can be counterbalanced by increasing the number of distinct bonds. This approach enables precise targeting of specific structural binding angles across a broad range of configurations by eliminating unfavorable interactions. 

The elastic moduli of tissues are connected to their states of health and function. The epithelial monolayer is a simple, minimal, tissue model that is often used to gain understanding of mechanical behavior at the cellular or multi-cellular scale. Here we investigate how the elastic modulus of Madin Darby Canine Kidney (MDCK) cells depends on their packing density. Rather than measuring elasticity at the sub-cellular scale with local probes, we characterize the monolayer at the multicellular scale, as one would a thin slab of elastic material. We use a micro-indentation system to apply gentle forces to the apical side of MDCK monolayers, applying a normal force to approximately 100 cells in each experiment. In low-density confluent monolayers, we find that the elastic modulus decreases with increasing cell density. At high densities, the modulus appears to plateau. This finding will help guide our understanding of known collective behaviors in epithelial monolayers and other tissues where variations in cell packing density are correlated with cell motion. 

The study of $$ \overline{B}\to {D}^{\ast}\tau {\overline{\nu}}_{\tau } $$angular distribution can be used to obtain information about new physics (or beyond the Standard Model) couplings, which are motivated by various B anomalies. However, the inability to measure precisely the three-momentum of the lepton hinders such measurements, as the tau decay contains one or more undetected neutrinos. Here, we present a measurable angular distribution of $$ \overline{B}\to {D}^{\ast}\tau {\overline{\nu}}_{\tau } $$ by considering the additional decay $$ \tau \to \ell {\nu}_{\tau }{\overline{\nu}}_{\ell } $$, wℓ. The full process used is$$ \overline{B}\to {D}^{\ast}\left(\to D\pi \right)\tau \left(\to \ell {\nu}_{\tau }{\overline{\nu}}_{\ell}\right){\overline{\nu}}_{\tau } $$ $\overline{B}\to D^{\ast }\left(\to \mathrm{D\pi }\right)\tau \left(\to \ell {\nu }_{\tau }{\overline{\nu }}_{\ell }\right){\overline{\nu }}_{\tau }$, in which only theℓandD^*are reconstructed. A fit to the experimental angular distribution of this process can be used to extract information on new physics parameters. To demonstrate the feasibility of this approach, we generate simulated data for this process and perform a sensitivity study to obtain the expected statistical errors on new physics parameters from experiments in the near future. We obtain a sensitivity of the order of 5% for the right-handed current and around 6% for the tensor current. In addition, we use the recent lattice QCD data onB→D^*form factors and obtain correlations between form factors and new physics parameters.